High school seniors Logan and Blake prepare for an epic Spring Break as they travel to the beautiful and exotic Mexican beach resort of Puerto Vallarta hoping to hook up with their high school crushes. Surrounded by hot girls in teeny bikinis, the guys are truly in heaven. After meeting at a club, Logan falls for a mysterious local beauty named Gaby but then realizes the next morning, when his grandfather's Rolex watch is missing, that she was after more than just his heart. Things go from bad to worse when the guys discover that the valuable family heirloom is now in the hands of a gangster who demands to be paid triple the watch's value before returning it. And that's just the beginning...

Four paramedics on duty in Arizona intercept a distress call from Mexico. Training kicks in as they illegally cross the border to help. Suddenly trapped inside their own ambulance, nothing could prepare them for what they would encounter.